1.Grape SEED extract

The cardio vascular health benefits of grape seed extract (GSE) have been researched extensively. The mechanism of action appears to be related to its antioxidant activity. Studies in rats and rabbits have shown that GSE consumption increased the antioxidant capacity of plasma, inhibited Low Density Lipoprotein oxidation, increased Nitrous Oxide and protected against ischemia/reperfusion injuries ⁹,¹⁰,¹¹ . Interestingly, in a single blind, randomized, placebo controlled, trial using a cross over design on human subjects GSE was shown to significantly increase serum antioxidant activity, confirming GSE had a physiological effect in in-vivo, consistent with in-vitro and animal studies.¹²

Tarac has completed a series of human clinical trials in collaboration with respected research institutes such as the CSIRO Health Sciences and Nutrition division. This research has shown that Vinlife® Grape Seed Extract can mediate vascular health.

2. Grape SKIN extract

Grapes and grape products, especially those made from the skins and stems of grapes, are good sources of flavonoids. Red Grape Skin extract contains a mix of substances, some of which are found in grape seeds and some in red wine. These substances include non-bioflavonoid polyphenols (derivatives of cinnamic and benzoic acid) and bioflavonoid polyphenols (quercetin, catechins, flavonols, and anthocyanins).

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9 Facino RM, Carini M, Aldini G, Berti F, Rossoni G, Bombardelli E, Morazzoni P 1999, 'Diet enriched with procyanidins enhances antioxidant activity and reduces myocardial post-ischemic damage in rats', Life Sci 64(8):627-42.

10 Yamakoshi J, Kataoka S, Koga T, Ariga T 1999, 'Proanthocyanidin-rich extract from grape seeds attenuates the development of aortic atherosclerosis in cholesterol-fed rabbits', Atherosclerosis 142:139-49.

11 Koga T, Moro K, Nakamori K, Yamakoshi J, Hosoyama H, Kataoka S, Ariga T 1999, 'Increase of antioxidative potential of rat plasma by oral administration of proanthocyanidin-rich extract from grape seeds', Int J Tissue React 21(4):93-104.

12 Nuttall SL, Kendall MJ, Bombardelli E, Morazzoni P 1999, 'An evaluation of the antioxidant activity of a standardized grape seed extract, Leucoselect', Atherosclerosis 142(1):139-49.

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